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TRIB3-deficient cells exhibit elevated CHAC1 levels, leading to increased GSH consumption and higher susceptibility to arsenite toxicity

doi: 10.3389/fgene.2021.792231 Received 10 October 2021 Accepted 13 December 2021 Published 18 January 2022 Volume 12 - 2021 Edited by Antonella Izzo, University of Naples Federico II, Italy Reviewed by Leda Torres, National Institute of Pediatrics, Mexico Romina Cejas, University at Buffalo, United States Updates Copyright 2022 Venegas-Zamora, Bravo-Acua, Sigcho, Gomez, Bustamante-Salazar, Pedrozo and Parra

Methionine restriction constrains lipoylation and activates mitochondria for nitrogenic synthesis of amino acids

Morales, M., Martnez-Paz, P., Ozez, I., Martnez-Guitarte, J

Phosphorylated MLKL oligomerizes and translocates to the plasma membrane, where it forms pores that cause cell swelling, membrane rupture, and release of DAMP